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The in vitro metabolism studies described here provide the first data that quantitatively describes the kinetics of metabolism of gefitinib and erlotinib by individual CYP enzymes.

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To understand whether nuclear PKM2 was a possible target for gefitinib resistance, six CRC cell lines, HT29, SW480, SW620, LS174T, HCT116 and C2BBel, were employed to evaluate a possible correlation between gefitinib resistance and nuclear PKM2 expression levels.

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