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Here, we review new controversies and conclusions regarding the clinical implications of EGFR mutations in lung cancer, with a focus on EGFR TKI resistance.

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The expression levels of EGFR and actin were examined using an anti-myc antibody (9E10) and anti- actin antibody (AC-15).

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The in vitro metabolism studies described here provide the first data that quantitatively describes the kinetics of metabolism of gefitinib and erlotinib by individual CYP enzymes.

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To understand whether nuclear PKM2 was a possible target for gefitinib resistance, six CRC cell lines, HT29, SW480, SW620, LS174T, HCT116 and C2BBel, were employed to evaluate a possible correlation between gefitinib resistance and nuclear PKM2 expression levels.

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