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Here, we review new controversies and conclusions regarding the clinical implications of EGFR mutations in lung cancer, with a focus on EGFR TKI resistance.
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The expression levels of EGFR and actin were examined using an anti-myc antibody (9E10) and anti- actin antibody (AC-15).
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The in vitro metabolism studies described here provide the first data that quantitatively describes the kinetics of metabolism of gefitinib and erlotinib by individual CYP enzymes.
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With the rapid flow of scientific information, new evidence may emerge between the time a practice guideline or consensus statement is developed and when it is published or read.
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To understand whether nuclear PKM2 was a possible target for gefitinib resistance, six CRC cell lines, HT29, SW480, SW620, LS174T, HCT116 and C2BBel, were employed to evaluate a possible correlation between gefitinib resistance and nuclear PKM2 expression levels.
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On the other hand, in all cell lines, the sensitivity to the antiproliferative effect of gefitinib was also dose dependent and independent to the status of p53 and interestingly to the expression of EGFR.
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Cycles (higher dose followed by lower dose) will be repeated as long as subject's cancer does not worsen and they do not experience any serious side effects.
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